HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fluoroquinolonic acid → HCID 14839405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fluoroquinolonic acid | HCID 483180 | — |
| Reactant | 2-(Methoxymethyl)piperazine | HCID 14230264 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 14839405 | HCID 14839405 | 46.3% |
Reaction Steps
A mixture of 0.6 g of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine in 4 ml of pyridine was heated at 120°-130° C. under argon in a pressure bottle for 18 hours. The solvent was removed and the residue was chromatographed and the crude product triturated with methanol and ether, giving 370 mg of the desired product as white crystals, mp 215°-216° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04940710 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-691674d653b242c89dd82ffce57ff262 |
| Source note | uspto-grants-1990_07 |