Hydrochloric Acid → HCID 131716469, compound

HRID 2165666Notes

Reaction equation

HRID 2165666 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([F:22])[C:9]([F:21])=[C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[C:11]=2[F:13])[C:6](=[O:23])[C:5]([C:24]([OH:26])=[O:25])=[CH:4]1)[CH3:2].[ClH:27].CCCCCC.CCOCC>ClCCl>[ClH:27].[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([F:22])[C:9]([F:21])=[C:10]([N:14]3[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]3)[C:11]=2[F:13])[C:6](=[O:23])[C:5]([C:24]([OH:26])=[O:25])=[CH:4]1)[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 8058HexaneHCID 14300416HCID 14300416, compound

Product 1

HCID 131716469HCID 131716469, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 50 mg portion of 1-ethyl-5,6,8-trifluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid was dissolved in 50 ml of dichloromethane and acidified with hydrochloric acid. Hexane and ether were added, the mixture was filtered and the solid which formed was collected, washed with ether, then hexane and dried, giving the desired salt, mp 271°-273° C.

Workup

  1. filtrationthe mixture was filtered
  2. customthe solid which formed
  3. customwas collected
  4. washwashed with ether
  5. dry with materialhexane and dried

Sources & evidence

ORD record
ord-01cb305fe879456e8df9a55a6d071dfb
Source dataset
uspto-grants-1990_07
Patent number
US04940710

Reaction notes

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