Hydrochloric Acid → HCID 131716470, compound

HRID 2165677Notes

Reaction equation

HRID 2165677 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:25])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH:16]([C:20]5[CH:24]=[CH:23][S:22][CH:21]=5)[CH2:15]4)[CH:12]=3)[C:7](=[O:26])[C:6]([C:27]([OH:29])=[O:28])=[CH:5]2)[CH2:3][CH2:2]1.[ClH:30]>[OH-].[Na+]>[ClH:30].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:25])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH:16]([C:20]5[CH:24]=[CH:23][S:22][CH:21]=5)[CH2:15]4)[CH:12]=3)[C:7](=[O:26])[C:6]([C:27]([OH:29])=[O:28])=[CH:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14839400HCID 14839400, compound

Product 1

HCID 131716470HCID 131716470, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A 200 mg portion of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-thienyl)-1-piperazinyl]-3-quinolinecarboxylic acid was dissolved in 2 ml of 1N sodium hydroxide, then 10% aqueous hydrochloric acid was added until the pH was 3. The mixture was stirred for 30 minutes, then the solid was collected and dried, giving 170 mg of the desired product.

Workup

  1. customthe solid was collected
  2. customdried

Sources & evidence

ORD record
ord-e8c473d83e7f4cc295f6a2ee8e13daa6
Source dataset
uspto-grants-1990_07
Patent number
US04940710

Reaction notes

Loading…