HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2165679Generated: October 31, 2026
Fluoroquinolonic acid → 1-Cyclopropyl-7-(3-ethenyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
https://huagongshe.com/reaction/2165679
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Fluoroquinolonic acid | HCID 483180 | — |
| Reactant | 2-Ethenylpiperazine | HCID 15382901 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Cyclopropyl-7-(3-ethenyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15382910 | 12.7% |
Reaction Steps
A mixture of 1.3 g of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.9 g of 3-ethenylpiperazine and 15 ml of pyridine is heated at 140° C. in a pressure bottle for 18 hours and then purified as described in Example 101, giving 210 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04940710 |
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| Source dataset | uspto-grants-1990_07 |
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| ORD ID | ord-ec3bdeaa67154f22b568609b9d98bee3 |
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| Source note | uspto-grants-1990_07 |
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