4,4-Dimethyl-3-thiosemicarbazide → HCID 136404502, compound

HRID 2165735Notes

Reaction equation

HRID 2165735 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8]([OH:15])=[C:7]([CH3:16])[CH:6]=1)=O.[CH3:17][N:18]([CH3:23])[C:19](=[S:22])[NH:20][NH2:21]>C(O)C>[BrH:1].[C:11]([C:9]1[C:8]([OH:15])=[C:7]([CH3:16])[CH:6]=[C:5]([C:3]2[CH2:2][S:22][C:19]([N:18]([CH3:23])[CH3:17])=[N:20][N:21]=2)[CH:10]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 27337004,4-Dimethyl-3-thiosemicarbazideHCID 14210976HCID 14210976, compound

Product 1

HCID 136404502HCID 136404502, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 11.7 g (0.041 mol) of 2-bromo-1-(5-tert.butyl)-3-methyl-4-hydroxyphenyl)-ethanone from step (a) and 4.4 g (0.037 mol) of 4,4-dimethylthiosemicarbazide in 130 ml of ethanol was refluxed briefly. After cooling, the reaction mixture was worked up corresponding to Example 1(b).

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-b1e6f046519b49ad90178f2282fbedd0
Source dataset
uspto-grants-1990_07
Patent number
US04940790

Reaction notes

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