Acetic Acid → HCID 86744102, compound

HRID 2165785Notes

Reaction equation

HRID 2165785 reaction equation
[CH3:1][CH:2]=[CH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(O)(=O)C.[ClH:13]>>[ClH:13].[CH3:1][CH:2]=[CH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 8126Oct-2-ene

Product 1

HCID 86744102HCID 86744102, compound

Procedure

Under a nitrogen atmosphere, 2-(allyl carboxylate)-3-(monofluoroacetyl)-7-(R,S)-(t-butoxycarbonylamino)-8-oxo-1,5-diazabicyclo 3.3.0]octa-2-ene (190 mg, 0.5 mmol) was combined with a glacial acetic acid solution that was 3N in anhydrous hydrogen chloride (10 ml). The solution was stirred at room temperature for 10 minutes then concentrated in vacuo. The remaining volatiles on the concentrate were removed by azeotropic distillation with methylene chloride (2 x) to give 2-(allyl carboxylate)-3-(monofluoroacetyl)-7-(R,S)-amino-8-oxo-1,5-diazabicyclo 3.3.0]octa-2-ene hydrochloride.

Workup

  1. concentrationthen concentrated in vacuo
  2. customThe remaining volatiles on the concentrate were removed by azeotropic distillation with methylene chloride (2 x)

Sources & evidence

ORD record
ord-2d40ebab0764404a8c5606c64d079ca1
Source dataset
uspto-grants-1990_07
Patent number
US04940718

Reaction notes

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