HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-[(2-Methylquinolin-4-yl)amino]propane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Amino-1,2-propanediol | HCID 73561 | — |
| Reactant | 4-Chloro-2-methylquinoline | HCID 77973 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[(2-Methylquinolin-4-yl)amino]propane-1,2-diol | HCID 14209231 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of 4-chloro-2-methylquinoline (50 g) and 3-amino-1,2-propandiol (51 g) was heated at 160° C. for 1 hour. The mixture while still hot was poured into 700 ml of water. The mixture was saturated with potassium carbonate and cooled in an ice bath, whereupon the product crystallized. It was filtered and recrystallized from ethanol. The yield was 55 g, mp 167°-168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04942168 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-d7144421a1174c65aa74084ca306f64c |
| Source note | uspto-grants-1990_07 |