Methane → HCID 14209232, compound

HRID 2165832Notes

Reaction equation

HRID 2165832 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][CH2:13][CH:14]([OH:21])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.C.C([O-])(=O)C.[Na+].[H][H]>[Pd].CO.C(O)(=O)C>[OH:21][CH:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:13][NH:12][C:6]1[C:5]2[C:10](=[CH:11][CH:2]=[CH:3][CH:4]=2)[N:9]=[CH:8][CH:7]=1

Participants

8

Reactant 4

HCID 297MethaneHCID 517045Sodium AcetateHCID 14209230HCID 14209230, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14209232HCID 14209232, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

A mixture of 7-chloro-N-(2-hydroxy-2-phenylethyl)-4-quinolinamine (10 g), 0.8 g of palladium on powdered charcoal (10%), 5 ml of acetic acid, 7 g of sodium acetate 3H2O and 200 ml of methanol was hydrogenated at room temperature with shaking at 30-50 psi until completion of hydrogen uptake. The catalyst was filtered and the solvent evaporated. The oil residue was dissolved in 20 ml of water and the solution made alkaline (pH=10) with and NaOH solution. The crystalline compound was filtered and recrystallized from isopropanol. The yield was 7.5 g, mp 289°-290° C.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe catalyst was filtered
  3. customthe solvent evaporated
  4. dissolutionThe oil residue was dissolved in 20 ml of water
  5. filtrationThe crystalline compound was filtered
  6. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-2313e2bfbf7d40cbb8a8143e035dc9e5
Source dataset
uspto-grants-1990_07
Patent number
US04942168

Reaction notes

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