Ethanolamine → HCID 14209237, compound

HRID 2165837Notes

Reaction equation

HRID 2165837 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=2.[NH2:17][CH2:18][CH2:19][OH:20]>C(O)(C)C.O>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:17][CH2:18][CH2:19][OH:20])=[CH:9][CH:8]=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=2

Participants

5

Reactant 2

HCID 700EthanolamineHCID 455996403-Bromo-4-chloro-7-(trifluoromethyl)quinoline

Product 1

HCID 14209237HCID 14209237, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

A solution of 12.4 g of 3-bromo-4-chloro-7-trifluoromethylquinoline and 6.1 g of 2-aminoethanol in 30 ml of isopropanol was heated at reflux for 4 hours. The mixture was cooled and diluted with 150 ml of water and the solid was collected and recrystallized from isopropanol. The yield was 8.2 g, mp 140°-141° C.

Workup

  1. temperatureat reflux for 4 hours
  2. temperatureThe mixture was cooled
  3. customthe solid was collected
  4. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-e3a127e76720473e8fa1556b5695f8d0
Source dataset
uspto-grants-1990_07
Patent number
US04942168

Reaction notes

Loading…