Methanol → HCID 14628047, compound

HRID 2165936Notes

Reaction equation

[C:1]([C:4]1[CH:26]=[CH:25][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][C:13]2[NH:14][C:15]3[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[CH:18][C:16]=3[N:17]=2)=[C:6]([CH2:27][CH2:28][CH3:29])[C:5]=1[OH:30])(=[O:3])[CH3:2].C(N(CC)CC)C.[C:38](OC(=O)C)(=[O:40])[CH3:39].CO>CN(C)C1C=CN=CC=1.ClCCl>[C:38]([O:30][C:5]1[C:6]([CH2:27][CH2:28][CH3:29])=[C:7]([CH:25]=[CH:26][C:4]=1[C:1](=[O:3])[CH3:2])[O:8][CH2:9][CH2:10][CH2:11][S:12][C:13]1[NH:14][C:15]2[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[CH:18][C:16]=2[N:17]=1)(=[O:40])[CH3:39]

Participants

Conditions

Temperature: 0 °C

Procedure

A mixture of 2-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio]benzimidazole-5-carboxylic acid (1.50 g), triethylamine (4 ml), acetic anhydride (4 ml) and 4-dimethylaminopyridine (100 mg) in dichloromethane (50 ml) was stirred at 0 ° C. and then at room temperature for 5 hours. Methanol (4 ml) was added to the mixture, further stirred for an additional 30 minutes and then the mixture was evaporated. The residue was washed with water, dissolved in ethanol, and concentrated to dryness. The residue was purified by silica gel column chromatography, eluting with dichloromethane-ethyl acetate-methanol (10:2:1), and recrystallized from n-hexane-chloroform to give the title compound (970 mg, 58.2%) as yellow crystals, mp 85-87 ° C.

Workup

stirringfurther stirred for an additional 30 minutes
customthe mixture was evaporated
washThe residue was washed with water
dissolutiondissolved in ethanol
concentrationconcentrated to dryness
customThe residue was purified by silica gel column chromatography
washeluting with dichloromethane-ethyl acetate-methanol (10:2:1)
customrecrystallized from n-hexane-chloroform

Sources & evidence

ORD record: ord-a2ba410fe5704132a3db71ef8a4e6b17
Source dataset: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04942245

Reaction notes

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