Acetaldehyde → HCID 54376391, compound

HRID 2166018Notes

Reaction equation

HRID 2166018 reaction equation
[Br:1][CH:2]([CH3:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH:12](=O)[CH3:13].N1CCCCC1>C(Cl)Cl>[CH:12](=[C:4]([C:3](=[O:10])[CH:2]([Br:1])[CH3:11])[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:13]

Participants

5

Reactant 3

HCID 177AcetaldehydeHCID 8082PiperidineHCID 12780443Ethyl 4-bromo-3-oxopentanoate

Product 1

HCID 54376391HCID 54376391, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 100 g (0.45 mol) of ethyl 4-bromo-3-oxovalerate in 100 ml of absolute methylene chloride is cooled to -20° C. under nitrogen, and 50 g (1.12 mol) of acetaldehyde are added. 1 g of piperidine, dissolved in 10 ml of methylene chloride, is then added dropwise at -20° C.

Workup

  1. additionis then added dropwise at -20° C.

Sources & evidence

ORD record
ord-3c7c3aedd8764ff7acaf18b646f4b6f1
Source dataset
uspto-grants-1990_07
Patent number
US04943568

Reaction notes

Loading…