HCID 13922718, compound → HCID 13922720, compound

HRID 2166019Notes

Reaction equation

HRID 2166019 reaction equation
[Cl:1][C:2]1[S:6][C:5]([NH:7]C(OC(C)(C)C)=O)=[N:4][C:3]=1/[C:15](=[CH:19]/[CH3:20])/[C:16]([OH:18])=[O:17]>FC(F)(F)C(O)=O>[NH2:7][C:5]1[S:6][C:2]([Cl:1])=[C:3](/[C:15](=[CH:19]/[CH3:20])/[C:16]([OH:18])=[O:17])[N:4]=1

Participants

3

Reactant 1

HCID 13922718HCID 13922718, compound

Product 1

HCID 13922720HCID 13922720, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

0.7 g of Z-2-(5-chloro-2-tert.-butoxycarbonylaminothiazol-4-yl)but-2-enoic acid are dissolved in 5 ml of trifluoroacetic acid at 0° C. under nitrogen. The mixture is stirred at room temperature for one hour and evaporated in the cold and the residue is suspended in ethyl acetate. The pH is brought to 3.5 with saturated sodium bicarbonate solution, while stirring, the product first dissolving and then precipitating again. The product is filtered off with suction, washed with ethyl acetate and dried.

Workup

  1. customevaporated in the cold and the residue
  2. stirringwhile stirring
  3. dissolutionthe product first dissolving
  4. customprecipitating again
  5. filtrationThe product is filtered off with suction
  6. washwashed with ethyl acetate
  7. customdried

Sources & evidence

ORD record
ord-5d8703b4c4a14018bba292d38965920c
Source dataset
uspto-grants-1990_07
Patent number
US04943568

Reaction notes

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