1-Methylpiperazine → HCID 15005611, compound

HRID 2166024Notes

Reaction equation

HRID 2166024 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[O:8]=[C:9]1[NH:28][C:12]2=[N:13][C:14]3[CH:15]=[CH:16][C:17]([O:21][CH2:22][CH2:23][CH2:24][C:25]([OH:27])=O)=[CH:18][C:19]=3[CH:20]=[C:11]2[NH:10]1>>[O:8]=[C:9]1[NH:28][C:12]2=[N:13][C:14]3[CH:15]=[CH:16][C:17]([O:21][CH2:22][CH2:23][CH2:24][C:25]([N:5]4[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]4)=[O:27])=[CH:18][C:19]=3[CH:20]=[C:11]2[NH:10]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 142809904-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid

Product 1

HCID 15005611HCID 15005611, compound

Procedure

Reaction of N-methylpiperazine and 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butyric acid (2 g) analogously to the procedure of Example 4 gave the title compound as the hydrated dihydrochloride salt; yield 2.85 g (92%), m.p. 286°-288° C. (dec.).

Sources & evidence

ORD record
ord-fc42baa962504681a87efc2524b59984
Source dataset
uspto-grants-1990_07
Patent number
US04943573

Reaction notes

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