1-Thiophen-2-ylmethyl-piperazine → HCID 15005630, compound

HRID 2166025Notes

Reaction equation

HRID 2166025 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[O:13]=[C:14]1[NH:33][C:17]2=[N:18][C:19]3[CH:20]=[CH:21][C:22]([O:26][CH2:27][CH2:28][CH2:29][C:30](O)=[O:31])=[CH:23][C:24]=3[CH:25]=[C:16]2[NH:15]1>>[O:13]=[C:14]1[NH:33][C:17]2=[N:18][C:19]3[CH:20]=[CH:21][C:22]([O:26][CH2:27][CH2:28][CH2:29][C:30]([N:10]4[CH2:9][CH2:8][N:7]([CH2:6][C:2]5[S:1][CH:5]=[CH:4][CH:3]=5)[CH2:12][CH2:11]4)=[O:31])=[CH:23][C:24]=3[CH:25]=[C:16]2[NH:15]1

Participants

3

Reactant 2

HCID 5662081-Thiophen-2-ylmethyl-piperazineHCID 142809904-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid

Product 1

HCID 15005630HCID 15005630, compound

Procedure

Reaction of N-(2-thienylmethyl)piperazine and 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butyric acid (2 g) analogously to the procedure of Example 4 gave the title compound after suspending in methanol as the dihydrochloride salt; yield 3.50 g (95%), m.p. 244°-245° C. (dec).

Sources & evidence

ORD record
ord-5c7b975bd7a641e5824853f5cdd66f12
Source dataset
uspto-grants-1990_07
Patent number
US04943573

Reaction notes

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