1-(2-Pyrimidinyl)piperazine → HCID 15005637, compound

HRID 2166027Notes

Reaction equation

HRID 2166027 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[O:13]=[C:14]1[NH:33][C:17]2=[N:18][C:19]3[CH:20]=[CH:21][C:22]([O:26][CH2:27][CH2:28][CH2:29][C:30](O)=[O:31])=[CH:23][C:24]=3[CH:25]=[C:16]2[NH:15]1>>[O:13]=[C:14]1[NH:33][C:17]2=[N:18][C:19]3[CH:20]=[CH:21][C:22]([O:26][CH2:27][CH2:28][CH2:29][C:30]([N:10]4[CH2:11][CH2:12][N:7]([C:2]5[N:3]=[CH:4][CH:5]=[CH:6][N:1]=5)[CH2:8][CH2:9]4)=[O:31])=[CH:23][C:24]=3[CH:25]=[C:16]2[NH:15]1

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 142809904-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid

Product 1

HCID 15005637HCID 15005637, compound

Procedure

Reaction of N-(2-pyrimidinyl)piperazine and 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butyric acid (2 g) analogously to the procedure of Example 4 gave the title compound as the hydrated dihydrochloride salt; yield 3.67 g (100%), m.p. 184°-187° C.

Sources & evidence

ORD record
ord-f2569455111a45da9363ed8f927e35d9
Source dataset
uspto-grants-1990_07
Patent number
US04943573

Reaction notes

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