HCID 59189740, compound → HCID 59189728, compound

HRID 216618Notes

Reaction equation

HRID 216618 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH:12]([C:16]#[N:17])[C:13]([NH2:15])=[O:14]>O1CCOCC1>[NH2:17][C:16]1[NH:1][C:2]2[C:3]([C:12]=1[C:13]([NH2:15])=[O:14])=[CH:4][CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=2

Participants

3

Reactant 1

HCID 59189740HCID 59189740, compound2×

Product 1

HCID 59189728HCID 59189728, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

1,4-Dioxane (40 mL) was added to 2-(2-amino-4-trifluoromethylphenyl)-2-cyanoacetamide (Reference compound 21-1, 0.98 g, 4.0 mmol), and the mixture was stirred at 100° C. for 36 hours. After the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography to give the title reference compound (0.50 q) as a brown solid (yield 51%).

Workup

  1. customAfter the solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-baede16104c1429c964acb51797e3b63
Source dataset
uspto-grants-2012_06
Patent number
US08193237B2

Reaction notes

Loading…