Acetic Acid → HCID 14832607, compound

HRID 2166182Notes

Reaction equation

HRID 2166182 reaction equation
C([N:4]1[CH:8]([C:9](=[O:11])[CH3:10])[CH2:7][CH2:6][C:5]1=[O:12])(=O)C.[C:13](O)(=[O:15])[CH3:14]>[Pt]>[C:13]([O:11][CH:9]([CH:8]1[NH:4][C:5](=[O:12])[CH2:6][CH2:7]1)[CH3:10])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 322651HCID 322651, compound

Product 1

HCID 14832607HCID 14832607, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Conditions

Temperature
90 °C

Procedure

A mixture of 1,5-diacetylpyrrolidin-2-one (3.5 g), 5 percent platinum on alumina (1.0 g) and acetic acid (30 ml) is stirred in a 200-ml Parr® pressure vessel under a hydrogen atmosphere (570 psi) at 90° C. for 17.5 hours. Analysis of the reaction mixture after the removal of catalyst and solvent by nuclear magnetic resonance shows that it is a 1:1 mixture of the reactant and the desired product.

Workup

  1. customAnalysis of the reaction mixture after the removal of catalyst and solvent by nuclear magnetic resonance
  2. additiona 1:1 mixture of the reactant

Sources & evidence

ORD record
ord-675bcece0aed4cb08db15a1e9baa1474
Source dataset
uspto-grants-1990_07
Patent number
US04943640

Reaction notes

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