Dimethylamine → HCID 23039269, compound

HRID 2166308Notes

Reaction equation

HRID 2166308 reaction equation
[CH3:1][NH:2][CH3:3].[F:4][CH:5]([F:29])[O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH:16][C:17]([NH:19][C:20]1[N:25]=[C:24](Cl)[N:23]=[C:22]([O:27][CH3:28])[N:21]=1)=[O:18])(=[O:15])=[O:14]>O1CCOCC1.Cl>[F:4][CH:5]([F:29])[O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH:16][C:17]([NH:19][C:20]1[N:25]=[C:24]([N:2]([CH3:3])[CH3:1])[N:23]=[C:22]([O:27][CH3:28])[N:21]=1)=[O:18])(=[O:15])=[O:14]

Participants

5

Reactant 2

HCID 674DimethylamineHCID 13729470N-(2-difluoromethoxyphenylsulfonyl)-N'-(4-chloro-6-methoxy-1,3,5-triazin-2-yl)-urea

Product 1

HCID 23039269HCID 23039269, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

3.0 g of dimethylamine are introduced at 20°-30° C., with cooling, into a solution of 8.2 g of N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-chloro-6-methoxy-1,3,5-triazin-2-yl)-urea in 80 ml of dioxane. After the formed suspension has been stirred for a further 30 minutes, it is taken up in 500 ml of 0.1N hydrochloric acid, and the product which has precipitated is separated by filtration; yield: 7.7 g of N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-dimethylamino-6-methoxy-1,3,5-triazin-2-yl)-urea, m.p. 171°-172° C.

Workup

  1. customthe product which has precipitated
  2. customis separated by filtration

Sources & evidence

ORD record
ord-38a965a6b8fb4d629a35ef5a6c178447
Source dataset
uspto-grants-1990_07
Patent number
US04944792

Reaction notes

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