HCID 24987950, compound → HCID 24989061, compound

HRID 216631Notes

Reaction equation

HRID 216631 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]2[C:12]([C:13]=1[C:14]([NH2:16])=[O:15])=[CH:11][CH:10]=[C:9]([CH:17]=[CH2:18])[CH:8]=2)=[O:3]>CO.[Pd]>[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]2[C:12]([C:13]=1[C:14]([NH2:16])=[O:15])=[CH:11][CH:10]=[C:9]([CH2:17][CH3:18])[CH:8]=2)=[O:3]

Participants

4

Reactant 1

HCID 24987950HCID 24987950, compound2×

Product 1

HCID 24989061HCID 24989061, compoundYield 52%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5% Palladium-activated carbon (19 mg) was added to a solution of 2-aminocarbonylamino-6-vinylindole-3-carboxamide (Compound 4-38, 18 mg, 0.073 mmol) in methanol (3 mL), and was stirred at room temperature for 4 hours under hydrogen atmosphere. After the reaction mixture was filtered throught Celite® pad, the filtrate was concentrated under reduced pressure to give the title compound (9.3 mg) as an off-white solid (yield 52%).

Workup

  1. filtrationAfter the reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c6b5c38c09464266b6472e58b11d4a31
Source dataset
uspto-grants-2012_06
Patent number
US08193237B2

Reaction notes

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