4-Ethylbenzyl alcohol → HCID 14577285, compound

HRID 2166334Notes

Reaction equation

HRID 2166334 reaction equation
[Cl:1][C:2]([CH3:16])([CH2:13][CH2:14][CH3:15])[CH2:3][N:4]1[C:9](=[O:10])[C:8]([Cl:11])=[C:7](Cl)[CH:6]=[N:5]1.[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23][OH:24])=[CH:21][CH:20]=1)[CH3:18].[OH-].[K+]>CN(C)C=O>[Cl:11][C:8]1[C:9](=[O:10])[N:4]([CH2:3][C:2]([Cl:1])([CH3:16])[CH2:13][CH2:14][CH3:15])[N:5]=[CH:6][C:7]=1[O:24][CH2:23][C:22]1[CH:25]=[CH:26][C:19]([CH2:17][CH3:18])=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 130344-Ethylbenzyl alcoholHCID 14797Potassium HydroxideHCID 23039513HCID 23039513, compound

Product 1

HCID 14577285HCID 14577285, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 20 ml of N,N-dimethylformamide were added 1.2 g of 2-(2-chloro-2-methylpentyl)-4,5-dichloro-3(2H)-pyridazinone and 0.64 g of 4-ethylbenzyl alcohol, and thereto was added 0.31 g of powdery potassium hydroxide under ice-cooling and stirred for one day at room temperature. Then, the procedures in Preparation Example 2 were repeated to give 600 mg of the intended compound.

Workup

  1. temperaturecooling
  2. customThen, the procedures in Preparation Example 2

Sources & evidence

ORD record
ord-b8f00a26f74441109ed11c3d4c7d892c
Source dataset
uspto-grants-1990_07
Patent number
US04945091

Reaction notes

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