Piperazin-2-one → HCID 23039543, compound

HRID 2166345Notes

Reaction equation

HRID 2166345 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][N:11]([CH2:13][C:14]([O:16]N3C(=O)CCC3=O)=O)[C:10](=[O:24])[CH2:9]2)=[CH:4][CH:3]=1.[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][C:26]1=[O:31]>CN(C)C=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][N:11]([CH2:13][C:14]([N:28]3[CH2:29][CH2:30][NH:25][C:26](=[O:31])[CH2:27]3)=[O:16])[C:10](=[O:24])[CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 231360Piperazin-2-oneHCID 86744118HCID 86744118, compound

Product 1

HCID 23039543HCID 23039543, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

10 g (30 mmol) of N-[4-(p-fluorophenyl)-2-oxopyrrolidin-1-ylacetoxy]-succinimide and 3.0 g (30 mmol) of piperazin-2-one (ketopiperazine) are stirred at room temperature in 100 ml of dimethylformamide for 16 hours. The whole is concentrated to dryness by evaporation at 70° under reduced pressure, extracted at boiling temperature with trichloromethane, allowed to cool, filtered with suction and allowed to dry in the air. 1-[4-(p-fluorophenyl)-2-oxopyrrolidin-1-ylacetyl]-3-oxopiperazine having a melting point of 200°-203° is obtained.

Workup

  1. concentrationThe whole is concentrated to dryness by evaporation at 70° under reduced pressure
  2. extractionextracted
  3. temperatureto cool
  4. filtrationfiltered with suction
  5. customto dry in the air

Sources & evidence

ORD record
ord-bb8deed52be448fe9135283bdbe2dec2
Source dataset
uspto-grants-1990_07
Patent number
US04945092

Reaction notes

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