Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → 5-Phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 5-Phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester | HCID 13800071 | — |
| 촉매 | Titanium cation (4+) | HCID 114942 | — |
| 생성물 | 5-Phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester | HCID 13800101 | 82% |
반응 단계
540 mg of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester in 30 ml of isopropanol is refluxed with 0.2 ml of titanium(IV) isopropylate for 2 hours. After concentration, it is mixed with 0.5N hydrochloric acid and extracted with ethyl acetate. The ethyl acetate phase is dried, filtered and concentrated and digested with diisopropyl ether. 450 mg (82% of theory) of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester with a melting point of 207°-209° C. is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04945090 |
| 출처 데이터셋 | uspto-grants-1990_07 |
| ORD ID | ord-b74cf49a576c4185baf6b4e3477a2c00 |
| 출처 메모 | uspto-grants-1990_07 |