反应详情

540 mg of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester in 30 ml of isopropanol is refluxed with 0.2 ml of titanium(IV) isopropylate for 2 hours. After concentration, it is mixed with 0.5N hydrochloric acid and extracted with ethyl acetate. The ethyl acetate phase is dried, filtered and concentrated and digested with diisopropyl ether. 450 mg (82% of theory) of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester with a melting point of 207°-209° C. is obtained.

1. concentrationAfter concentration, it
2. additionis mixed with 0.5N hydrochloric acid
3. extractionextracted with ethyl acetate
4. dry with materialThe ethyl acetate phase is dried
5. filtrationfiltered
6. concentrationconcentrated