反应详情

300 mg of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid is heated with 2 ml of aminal ester for 3 hours to 120° C., whereby a solution is produced. After diluting with water, it is extracted with ethyl acetate. The organic phase is dreid, filtered, concentrated and chromatographed over silica gel with acetone:hexane=1:1 as eluant. 130 mg of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid t-butyl ester with a decomposition point of 150° C. is obtained.

1. customis produced
2. extractionis extracted with ethyl acetate
3. filtrationfiltered
4. concentrationconcentrated
5. customchromatographed over silica gel with acetone