5-Phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid → 5-Phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid t-butyl ester

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Reaction Steps

300 mg of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid is heated with 2 ml of aminal ester for 3 hours to 120° C., whereby a solution is produced. After diluting with water, it is extracted with ethyl acetate. The organic phase is dreid, filtered, concentrated and chromatographed over silica gel with acetone:hexane=1:1 as eluant. 130 mg of 5-phenoxy-4-methoxymethyl-beta-carboline-3-carboxylic acid t-butyl ester with a decomposition point of 150° C. is obtained.

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