Methyl iodide → HCID 14405656, compound

HRID 2166373Notes

Reaction equation

HRID 2166373 reaction equation
[I:1][CH3:2].[N:3]1[CH:8]=[CH:7][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:5][CH:4]=1>C(OCC)(=O)C>[I-:1].[CH3:2][N+:3]1[CH:4]=[CH:5][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 4137929HCID 4137929, compound

Product 1

HCID 14405656HCID 14405656, compoundYield 86.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2 ml, equivalent to 4.26 g (30.2 mmol) of iodomethane and 6 g (25.2 mmol) of 2-[(4-pyridyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline are introduced into 200 ml of ethyl acetate, and the mixture is stirred for 24 h at room temperature. A yellow precipitate forms, which is filtered off and washed with ether. 8.3 g of product are obtained, this being used without further treatment in the following stage.

Workup

  1. filtrationA yellow precipitate forms, which is filtered off
  2. washwashed with ether

Sources & evidence

ORD record
ord-0cebb6095cff473b886318f6ed940e4a
Source dataset
uspto-grants-1990_07
Patent number
US04945096

Reaction notes

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