Methane → HCID 883945, compound

HRID 2166375Notes

Reaction equation

HRID 2166375 reaction equation
C1(C[N:8]2[CH2:13][CH2:12][CH:11]([C:14]([N:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17]3)=[O:15])[CH2:10][CH2:9]2)C=CC=CC=1.C>C(O)(=O)C>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]([N:16]2[CH2:25][CH2:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17]2)=[O:15])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 297MethaneHCID 14405661HCID 14405661, compound

Product 1

HCID 883945HCID 883945, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

115 g (0.34 mol) of 2-[(1-phenylmethyl-4-piperidyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline are dissolved in 1 l of acetic acid, 4 g of palladinized charcoal (10% palladium) are added and the mixture is subjected to a hydrogenation at 75° C. under 0.35 MPa.

Workup

  1. customis subjected to a hydrogenation at 75° C. under 0.35 MPa

Sources & evidence

ORD record
ord-d343deff31904043ba9c6fd33ee9d3d4
Source dataset
uspto-grants-1990_07
Patent number
US04945096

Reaction notes

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