Thiazole → 1-Octadecylaminocarbonyloxy-3-[6-(3-thiazolio)hexanoyloxy]-2-methylenepropane bromide

HRID 2166449Notes

Reaction equation

HRID 2166449 reaction equation
[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:35])[CH2:25][O:26][C:27](=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][Br:33])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[S:36]1[CH:40]=[CH:39][N:38]=[CH:37]1>>[Br-:33].[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:35])[CH2:25][O:26][C:27](=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][N+:38]1[CH:39]=[CH:40][S:36][CH:37]=1)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 9256ThiazoleHCID 140646451-Octadecylaminocarbonyloxy-3-(6-bromohexanoyloxy)-2-methylenepropane

Product 1

HCID 679375811-Octadecylaminocarbonyloxy-3-[6-(3-thiazolio)hexanoyloxy]-2-methylenepropane bromide

Procedure

1-Octadecylaminocarbonyloxy-3-(6-bromohexanoyloxy)-2-methylenepropane (from Preparation 9) (0.55 g) and thiazole (2.5 ml) were heated to 110° C. for 4 hours. The reaction mixture was evaporated to dryness in vacuo.

Workup

  1. customThe reaction mixture was evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-e07475132f504da3b608ac0f62298f9e
Source dataset
uspto-grants-1990_07
Patent number
US04945098

Reaction notes

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