Sulfur → HCID 13189085, compound

HRID 2166557Notes

Reaction equation

HRID 2166557 reaction equation
[CH:1]1([CH2:4][N:5]2[C:14]3[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=3)[CH:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[NH:7][C:6]2=[S:23])[CH2:3][CH2:2]1.[S]>ClC1C=CC=CC=1Cl>[CH:1]1([CH2:4][N:5]2[C:14]3[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=3)[C:8]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[N:7][C:6]2=[S:23])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 5362487SulfurHCID 20499629HCID 20499629, compound

Product 1

HCID 13189085HCID 13189085, compoundYield 78.3%

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

A mixture of 1.62 g of 1-cyclopropylmethyl-4-phenyl-6-methoxy-3,4-dihydro-2(1H)-quinazolinethione, 0.48 g of sulfur and 10 ml of o-dichlorobenzene was stirred under reflux for 5 hours. The solvent was then removed under reduced pressure and the residue was chromatographed on a silica gel column, eluting with chloroform to give 1.26 g of 1-cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinethione, m.p. 180°-181° C.

Workup

  1. temperatureunder reflux for 5 hours
  2. customThe solvent was then removed under reduced pressure
  3. customthe residue was chromatographed on a silica gel column
  4. washeluting with chloroform

Sources & evidence

ORD record
ord-25c3fac767f34e3084320320f08aa6fa
Source dataset
uspto-grants-1983_06
Patent number
US04387223

Reaction notes

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