反应详情

A solution of 1-benzyl-1,6-dihydro-5-(p-trifluoromethylphenyl)-3-(2H)pyridone hydrochloride hydrate (11.6 g) in ethanol (250 ml) was treated with sodium bicarbonate (2 g) followed by sodium borohydride (1.5 g). After 2 hours the solvents were removed under reduced pressure and the residue partitioned between water (100 ml) and ether (400 ml). The organic phase was dried and the solvent removed under reduced pressure. Recrystallisation of the residue from cyclohexane gave the title compound (7.3 g), m.p. 88°-90°.

1. customAfter 2 hours the solvents were removed under reduced pressure
2. customthe residue partitioned between water (100 ml) and ether (400 ml)
3. customThe organic phase was dried
4. customthe solvent removed under reduced pressure
5. customRecrystallisation of the residue from cyclohexane