HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Benzyl-1,6-dihydro-5-(p-chlorophenyl)-3[2H]-pyridone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Benzyl-5-methoxy-1,2,3,6-tetrahydropyridin-3-one | HCID 12900693 | — |
| Reactant | HCID 178478191 | HCID 178478191 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-1,6-dihydro-5-(p-chlorophenyl)-3[2H]-pyridone | HCID 12900702 | — |
Reaction Steps
A solution of p-chlorophenyl magnesium bromide (0.17 M) in ether (100 ml) was treated with a solution of 1-benzyl-1,6-dihydro-5-methoxy-3-[2H]pyridone (32.5 g, 0.25 M) in THF (150 ml). The reaction was stirred 1 hour, poured onto cold 2 N hydrochloric acid (250 ml) and stirred 30 min. Removal of the resulting precipitate by filtration, followed by air-drying and recrystallisation from methanol gave the title compound as the hydrochloride hydrate (24.1 g) m.p. 166°-8°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04387230 |
| Source dataset | uspto-grants-1983_06 |
| ORD ID | ord-88a9f8aa0d52473b8e5a26de981bc5bc |
| Source note | uspto-grants-1983_06 |