Hydrochloric Acid → HCID 12900702, Verbindung

HRID 2166570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2166570
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Mg]Br)=[CH:4][CH:3]=1.[CH2:10]([N:17]1[CH2:22][C:21](OC)=[CH:20][C:19](=[O:25])[CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.Cl>CCOCC.C1COCC1>[CH2:10]([N:17]1[CH2:22][C:21]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:20][C:19](=[O:25])[CH2:18]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 129006931-Benzyl-5-methoxy-1,2,3,6-tetrahydropyridin-3-oneHCID 178478191HCID 178478191, Verbindung

Produkt 1

HCID 12900702HCID 12900702, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of p-chlorophenyl magnesium bromide (0.17 M) in ether (100 ml) was treated with a solution of 1-benzyl-1,6-dihydro-5-methoxy-3-[2H]pyridone (32.5 g, 0.25 M) in THF (150 ml). The reaction was stirred 1 hour, poured onto cold 2 N hydrochloric acid (250 ml) and stirred 30 min. Removal of the resulting precipitate by filtration, followed by air-drying and recrystallisation from methanol gave the title compound as the hydrochloride hydrate (24.1 g) m.p. 166°-8°.

Aufarbeitung

  1. stirringstirred 30 min
  2. customRemoval of the resulting precipitate
  3. filtrationby filtration
  4. customby air-drying
  5. customrecrystallisation from methanol

Quellen und Nachweise

ORD-Eintrag
ord-88a9f8aa0d52473b8e5a26de981bc5bc
Quelldatensatz
uspto-grants-1983_06
Patentnummer
US04387230

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