Cyclopentylamine → HCID 13150834, compound

HRID 2166594Notes

Reaction equation

HRID 2166594 reaction equation
[O:1]1[CH:6]([C:7]([OH:9])=[O:8])[CH:2]1[C:3]([OH:5])=O.[CH2:10]([K])[CH3:11].C(Cl)(=O)C(Cl)=O.[CH:19]1([NH2:24])[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([NH:24][C:3](=[O:5])[CH:2]2[O:1][CH:6]2[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 2906CyclopentylamineHCID 65578Oxalyl chlorideHCID 178461626HCID 178461626, compound

Product 1

HCID 13150834HCID 13150834, compoundYield 62.6%

Procedure

Following the procedure of Example 1, monoethyl potassium epoxysuccinate (1.0 g) was successively treated with oxalyl chloride (0.75 g) and cyclopentylamine (0.86 g) to give 0.71 g of ethyl N-cyclopentyl-2,3-epoxysuccinamate (Compound No. 18) as colorless needles melting at 94°-97° C.

Sources & evidence

ORD record
ord-27ad475fac054643a341a5fb3a39379e
Source dataset
uspto-grants-1983_06
Patent number
US04387238

Reaction notes

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