Cyclohexylamine → HCID 13150836, compound

HRID 2166595Notes

Reaction equation

[O:1]1[CH:6]([C:7]([OH:9])=[O:8])[CH:2]1[C:3]([OH:5])=O.[CH2:10]([K])[CH3:11].C(Cl)(=O)C(Cl)=O.[CH:19]1([NH2:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([NH:25][C:3](=[O:5])[CH:2]2[O:1][CH:6]2[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

Reactant 3

HCID 7965Cyclohexylamine

HCID 65578Oxalyl chloride

HCID 178461626HCID 178461626, compound

Product 1

HCID 13150836HCID 13150836, compoundYield 58.1%

Procedure

Following the procedure of Example 1, monoethyl potassium epoxysuccinate (5 g) was successively treated with oxalyl chloride (3.72 g) and cyclohexylamine (5 g) to give 3.5 g of ethyl N-cyclohexyl-2,3-epoxysuccinamate (Compound No. 19) as colorless needles melting at 98°-100° C.

Sources & evidence

ORD record: ord-f98b24ecf154458d8ae5f9ec9d52dd16
Source dataset: uspto-grants-1983_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04387238

Reaction notes

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