Dimethylformamide dimethyl acetal → HCID 53924481, compound

HRID 2166668Notes

Reaction equation

HRID 2166668 reaction equation
C1([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[C:11](=[O:18])[CH2:10][CH2:9][N:8]=2)C=CC=CC=1.CO[CH:21](OC)[N:22]([CH3:24])[CH3:23]>>[CH3:21][N:22]([CH:24]=[C:10]1[C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH:7]=[N:8][CH2:9]1)[CH3:23]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 12948282HCID 12948282, compound

Product 1

HCID 53924481HCID 53924481, compound

Procedure

A mixture of 5.2 g (22 mmole) of 3,4-dihydro-1-phenyl-5H-2-benzazepin-5-one and 43 ml of dimethylformamide dimethyl acetal was refluxed for 4 hr. The mixture was concentrated at reduced pressure to dryness. The residue was crystallized with ether to give a yellow solid, mp 131°-133° C. Recrystallization from ether gave yellow prisms, mp 131°-132° C.

Workup

  1. temperaturewas refluxed for 4 hr
  2. concentrationThe mixture was concentrated at reduced pressure to dryness
  3. customThe residue was crystallized with ether
  4. customto give a yellow solid, mp 131°-133° C
  5. customRecrystallization from ether
  6. customgave yellow prisms, mp 131°-132° C.

Sources & evidence

ORD record
ord-5ebe591ab1374e6d8ea317539da97e0b
Source dataset
uspto-grants-1983_06
Patent number
US04388239

Reaction notes

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