HCID 20499079, compound → HCID 13135104, compound

Participants

Reaction Steps

A solution of methyl 2-amino-2-difluoromethyl-3-(5-imidazolyl)propionate dihydrochloride (10 g) in concentrated HCl is heated at reflux temperature for 16 hours. Concentration of the reaction mixture gives a residue which is passed on an Amberlite IR 120 H+ form resin column. Elution with a solution of HCl 2 M afforded the 2-amino-2-difluoromethyl-3-(5-imidazolyl)propionic acid hydrochloride which is recrystallized from water/ethanol.

Provenance & Evidence