HCID 20499079, compound → HCID 13135104, compound

HRID 2166746Notes

Reaction equation

HRID 2166746 reaction equation
[ClH:1].Cl.[NH2:3][C:4]([CH:15]([F:17])[F:16])([CH2:9][C:10]1[NH:14][CH:13]=[N:12][CH:11]=1)[C:5]([O:7]C)=[O:6]>Cl>[ClH:1].[NH2:3][C:4]([CH:15]([F:17])[F:16])([CH2:9][C:10]1[NH:14][CH:13]=[N:12][CH:11]=1)[C:5]([OH:7])=[O:6]

Participants

3

Reactant 1

HCID 20499079HCID 20499079, compound

Product 1

HCID 13135104HCID 13135104, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 2-amino-2-difluoromethyl-3-(5-imidazolyl)propionate dihydrochloride (10 g) in concentrated HCl is heated at reflux temperature for 16 hours. Concentration of the reaction mixture gives a residue which is passed on an Amberlite IR 120 H+ form resin column. Elution with a solution of HCl 2 M afforded the 2-amino-2-difluoromethyl-3-(5-imidazolyl)propionic acid hydrochloride which is recrystallized from water/ethanol.

Workup

  1. temperatureat reflux temperature for 16 hours
  2. customConcentration of the reaction mixture gives a residue which
  3. washElution with a solution of HCl 2 M

Sources & evidence

ORD record
ord-c89b70fa95ae401c9c4d48265b485d67
Source dataset
uspto-grants-1983_06
Patent number
US04388466

Reaction notes

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