Hydrochloric Acid → HCID 20499074, compound

HRID 2166748Notes

Reaction equation

HRID 2166748 reaction equation
[NH2:1][C:2]([CH2:12][F:13])([CH2:6][C:7]1[NH:11][CH:10]=[N:9][CH:8]=1)[C:3]([OH:5])=[O:4].[ClH:14].[CH3:15]O>>[ClH:14].[ClH:14].[NH2:1][C:2]([CH2:12][F:13])([CH2:6][C:7]1[NH:11][CH:10]=[N:9][CH:8]=1)[C:3]([O:5][CH3:15])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 107653α-Fluoromethylhistidine

Product 1

HCID 20499074HCID 20499074, compound

Procedure

A suspension of 4.4 g (0.024 mole) of 2-amino-2-fluoromethyl-3-(5-imidazolyl)propionic acid in 30 ml of methanol at 0° C. is saturated with dry hydrogen chloride after which the solution is heated under reflux for 12 hours. The solution is then concentrated and allowed to crystallize to afford methyl 2-amino-2-fluoromethyl-3-(5-imidazolyl)propionate, dihydrochloride (4.0 g).

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 12 hours
  3. concentrationThe solution is then concentrated
  4. customto crystallize

Sources & evidence

ORD record
ord-03f932b77bb6427b9cffe2782e2e20a4
Source dataset
uspto-grants-1983_06
Patent number
US04388466

Reaction notes

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