HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Amino-2-chloro-3-(p-nitrophenyl)sulfinylpropane trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-BOC 1-amino-2-chloro-3-(p-nitrophenyl)sulfinylpropane | HCID 53988848 | — |
| Solvent | Anisole | HCID 7519 | — |
| Product | 1-Amino-2-chloro-3-(p-nitrophenyl)sulfinylpropane trifluoroacetate | HCID 20130182 | — |
Reaction Steps
The product from Step C, 78 mg, is dissolved in 0.4 ml of anisole and treated at 0° C. for 10 minutes with 2.0 ml of trifluoroacetic acid (TFA). The TFA and anisole are pumped off at 20° C., and water and CH2Cl2 are added to the residue. The water layer is separated and evaporated, affording 66 mg of pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04388475 |
| Source dataset | uspto-grants-1983_06 |
| ORD ID | ord-5a299cfbd8fe429da506561275db66a1 |
| Source note | uspto-grants-1983_06 |