Hydrochloric Acid → HCID 22823406, compound

HRID 2166801Notes

Reaction equation

HRID 2166801 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C@H:9]([C:14]([NH:16][C:17]1[CH:26]=[C:25]2[C:20]([CH:21]=[C:22]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:23](=[O:27])[O:24]2)=[CH:19][CH:18]=1)=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12].[ClH:34]>CCOCC.CO>[ClH:34].[NH2:8][C@H:9]([C:14]([NH:16][C:17]1[CH:26]=[C:25]2[C:20]([CH:21]=[C:22]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:23](=[O:27])[O:24]2)=[CH:19][CH:18]=1)=[O:15])[CH2:10][CH:11]([CH3:12])[CH3:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22823408HCID 22823408, compound

Product 1

HCID 22823406HCID 22823406, compound

Reagents, catalysts & solvents 1

HCID 21864698Diethyl ether methanolSolvent

Procedure

The product of Example III, above, was dissolved in 9/1 ether/methanol and treated with hydrogen chloride gas until no more solid precipitated. The solid was redissolved in methanol and precipitated by addition of ether and dried overnight at room temperature and 0.1 Pa; mp 256.3° with decomposition.

Workup

  1. customprecipitated
  2. dissolutionThe solid was redissolved in methanol
  3. customprecipitated by addition of ether
  4. customdried overnight at room temperature

Sources & evidence

ORD record
ord-46c6b9c714bf4d6e86d09e83db9d9669
Source dataset
uspto-grants-1983_06
Patent number
US04388233

Reaction notes

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