Diethyl Sulfate → HCID 12854476, compound

HRID 2166879Notes

Reaction equation

HRID 2166879 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[C:5](=[O:13])[C:4]([CH:14]=[CH:15][C:16]([OH:18])=[O:17])=[CH:3]1.C(=O)([O-])[O-].[Na+].[Na+].S(OCC)(O[CH2:29][CH3:30])(=O)=O>CN(C=O)C>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[C:5](=[O:13])[C:4](/[CH:14]=[CH:15]/[C:16]([O:18][CH2:29][CH3:30])=[O:17])=[CH:3]1

Participants

5

Reactant 3

HCID 6163Diethyl SulfateHCID 10340Sodium CarbonateHCID 54550689HCID 54550689, compound

Product 1

HCID 12854476HCID 12854476, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-methyl-7-chloro-4(1H)-quinolone-3-acrylic acid (3.6 g) in dry DMF (150 ml) was stirred with anhydrous sodium carbonate (4.36 g) at 70° C. for one hour. To the reaction mixture was then added diethyl sulphate (5.06 g) dropwise, and then stirring at 70° C. was continued for twelve hours.

Workup

  1. waitwas continued for twelve hours

Sources & evidence

ORD record
ord-fdb9e111292f4f66a1304e5835b4e196
Source dataset
uspto-grants-1983_06
Patent number
US04390541

Reaction notes

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