Malonic Acid → HCID 12854470, compound

HRID 2166881Notes

Reaction equation

HRID 2166881 reaction equation
[CH:1]([C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1)=O.C(O)(=O)[CH2:15][C:16]([OH:18])=[O:17]>N1C=CC=CC=1>[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:12](=[O:13])[C:3](/[CH:1]=[CH:15]/[C:16]([OH:18])=[O:17])=[CH:4]1

Participants

4

Reactant 2

HCID 867Malonic AcidHCID 3481374-Hydroxyquinoline-3-carbaldehyde

Product 1

HCID 12854470HCID 12854470, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 3-formyl-4(1H)-quinolone (6 g) from Example 33 and malonic acid (18 g) in pyridine (300 ml) was heated on a steam bath for four hours. The reaction mixture was then evaporated down and the residue washed thoroughly with water. Recrystallisation from DMF/H2O gave the title compound, m.p. 242°-244° C.

Workup

  1. customThe reaction mixture was then evaporated down
  2. washthe residue washed thoroughly with water
  3. customRecrystallisation from DMF/H2O

Sources & evidence

ORD record
ord-b1d7bbfd3697421e834850a5ddb59aa5
Source dataset
uspto-grants-1983_06
Patent number
US04390541

Reaction notes

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