Fluorine → HCID 12886210, compound

HRID 2166931Notes

Reaction equation

HRID 2166931 reaction equation
[F:1]F.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=[O:16])[C:12]([O:14][CH3:15])=[O:13])=[CH:6][CH:5]=1>C(#N)C>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([F:1])[C:11](=[O:16])[C:12]([O:14][CH3:15])=[O:13])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 24524FluorineHCID 8008517HCID 8008517, compound

Product 1

HCID 12886210HCID 12886210, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In the same manner as in Example 1, methyl 3-(4-chlorophenyl)pyruvate is dissolved in acetonitrile (500 ml) and reacted with fluorine at -10° C. After the same work-up as in Example 1, the resulting crude product is rectified to give syrupy methyl 3-(4-chlorophenyl)-3-fluoropyruvate (7.49 g).

Sources & evidence

ORD record
ord-f289966e971c469487f778ca69f6a8b5
Source dataset
uspto-grants-1983_06
Patent number
US04390702

Reaction notes

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