反应详情

Methyl dichlorophosphine (1.3 g) in ether (10 ml) and triethylamine (2 ml) were added to a stirred solution of N-benzoyl-N'-t-butyl hydrazine (1.0 g) in methylene chloride (3 ml). After stirring 5 minutes at room temperature, o-chloroaniline was added neat producing a mild exotherm. The reaction was quenched 2 minutes later with water (20 ml) and ether (20 ml), separated and the organic washed with 0.1N HCl, dried over MgSO4, filtered and rotavapped to a colorless oil weighing 0.5 g.

1. customproducing a mild exotherm
2. customThe reaction was quenched 2 minutes later with water (20 ml) and ether (20 ml)
3. customseparated
4. washthe organic washed with 0.1N HCl
5. dry with materialdried over MgSO4
6. filtrationfiltered