Propionic anhydride → HCID 178460289, compound

HRID 2167016Notes

Reaction equation

C([O:5][NH:6][C:7](=[N:60]S(C1C(C)=C(C)C2OC(C)(C)CC=2C=1C)(=O)=O)[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:42][C:43](=[O:59])OCC1C2C=CC=CC=2C2C1=CC=CC=2)[C:14](=[O:41])[NH:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([N:25]2[C:29]([C:30]3[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=3)=[CH:28][C:27]([C:37]([F:40])([F:39])[F:38])=[N:26]2)=[CH:21][CH:20]=1)(=[O:18])=[O:17])(C)(C)C.[C:78](OC(=O)CC)(=O)[CH2:79]C>>[OH:5][N:6]=[C:7]([NH2:60])[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:42][C:43](=[O:59])[CH2:78][CH3:79])[C:14]([NH:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([N:25]2[C:29]([C:30]3[CH:31]=[CH:32][C:33]([CH3:36])=[CH:34][CH:35]=3)=[CH:28][C:27]([C:37]([F:40])([F:38])[F:39])=[N:26]2)=[CH:23][CH:24]=1)(=[O:17])=[O:18])=[O:41]

Participants

Reactant 2

HCID 31263Propionic anhydride

HCID 178423759HCID 178423759, compound

Product 1

HCID 178460289HCID 178460289, compound

Procedure

Compound (20a) is treated according to the methods of Example 16, with substitution of propionic anhydride as the acylating agent, to afford the title compound.

Sources & evidence

ORD record: ord-7a347a5ac1bd451188ca1c1c01322ca2
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09044464B2

Reaction notes

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