Tazobactam → 689293-68-3

HRID 2167045Notes

Reaction equation

HRID 2167045 reaction equation
C[C@@]1(CN2N=NC=C2)S(=O)(=O)[C@@H]2CC(=O)N2[C@H]1C(O)=O.[CH3:21][C:22]([O:27]/[N:28]=[C:29](\[C:36]([NH:38][C@@H:39]1[C:42](=[O:43])[N:41]2[C:44]([C:63]([OH:65])=[O:64])=[C:45]([CH2:48][N+:49]3[N:53]([CH3:54])[C:52]([NH2:55])=[C:51]([NH:56][C:57]([NH:59][CH2:60][CH2:61][NH2:62])=[O:58])[CH:50]=3)[CH2:46][S:47][C@H:40]12)=[O:37])/[C:30]1[N:31]=[C:32]([NH2:35])[S:33][N:34]=1)([C:24]([O-:26])=[O:25])[CH3:23].OS(O)(=O)=O>>[CH3:23][C:22]([O:27]/[N:28]=[C:29](\[C:36]([NH:38][C@@H:39]1[C:42](=[O:43])[N:41]2[C:44]([C:63]([OH:65])=[O:64])=[C:45]([CH2:48][N+:49]3[N:53]([CH3:54])[C:52]([NH2:55])=[C:51]([NH:56][C:57]([NH:59][CH2:60][CH2:61][NH2:62])=[O:58])[CH:50]=3)[CH2:46][S:47][C@H:40]12)=[O:37])/[C:30]1[N:31]=[C:32]([NH2:35])[S:33][N:34]=1)([C:24]([O-:26])=[O:25])[CH3:21]

Participants

3

Reactant 2

HCID 123630TazobactamHCID 49863419HCID 49863419, compound

Product 1

HCID 71457955689293-68-3

Procedure

lyophilizing a first aqueous solution in the absence of tazobactam, the first aqueous solution comprising ceftolozane sulfate prior to lyophilization to obtain a first lyophilized ceftolozane composition; and

Sources & evidence

ORD record
ord-0c93f87e2b674b0c81907c2cc4e71674
Source dataset
uspto-grants-2015_06
Patent number
US09044485B2

Reaction notes

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