HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tazobactam → 2-[(Z)-[2-[[(6R,7R)-3-[[5-amino-4-(2-aminoethylcarbamoylamino)-1-methylpyrazol-2-ium-2-yl]methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene]amino]oxy-2-methylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tazobactam | HCID 123630 | — |
| Reactant | HCID 49863419 | HCID 49863419 | — |
| Product | 2-[(Z)-[2-[[(6R,7R)-3-[[5-amino-4-(2-aminoethylcarbamoylamino)-1-methylpyrazol-2-ium-2-yl]methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene]amino]oxy-2-methylpropanoate | HCID 71457955 | — |
Reaction Steps
lyophilizing a first aqueous solution in the absence of tazobactam, the first aqueous solution comprising ceftolozane sulfate prior to lyophilization to obtain a first lyophilized ceftolozane composition; and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09044485B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-0c93f87e2b674b0c81907c2cc4e71674 |
| Source note | uspto-grants-2015_06 |