1,4-Dibromobutane → (1H-Benzimidazol-2-yl)-{3-[4-(3-pyrrolidin-1-yl-propyl)-piperazin-1-yl]-propyl}-amine

Participants

Role	Name	HCID	Charge
Reactant	1,4-Dibromobutane	HCID 8056	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	[3-[4-(3-Amino-propyl)-piperazin-1-yl]-propyl]-(1H-benzimidazol-2-yl)-amine	HCID 67412597	—
Solvent	Dimethylformamide	HCID 6228	—
Product	(1H-Benzimidazol-2-yl)-{3-[4-(3-pyrrolidin-1-yl-propyl)-piperazin-1-yl]-propyl}-amine	HCID 11588777	—

Reaction Steps

[3-[4-(3-Amino-propyl)-piperazin-1-yl]-propyl]-(1H-benzimidazol-2-yl)-amine (intermediate) (65 mg, 0.021 mmol) was dissolved in anhydrous DMF (20 mL) in the presence of potassium carbonate (142 mg, 1.0 mmol). 1,4-dibromobutane (0.03 mL, 0.25 mmol) was added. The resulting mixture was stirred for 48 h at room temperature. The

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09044478B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-32f1b143d5a94cdebe8378098966f5a2
Source note	uspto-grants-2015_06