反应详情

[3-[4-(3-Amino-propyl)-piperazin-1-yl]-propyl]-(1H-benzimidazol-2-yl)-amine (intermediate) (65 mg, 0.021 mmol) was dissolved in anhydrous DMF (20 mL) in the presence of potassium carbonate (142 mg, 1.0 mmol). 1,4-dibromobutane (0.03 mL, 0.25 mmol) was added. The resulting mixture was stirred for 48 h at room temperature. The