Water → HCID 11621005, compound

HRID 2167078Notes

Reaction equation

HRID 2167078 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:7][CH2:6]1.[CH:15]1[C:27]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:19]=2[CH:18]=[CH:17][C:16]=1[CH:28]=O.[BH4-].[Na+].O>C(O)C>[CH:15]1[C:27]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:19]=2[CH:18]=[CH:17][C:16]=1[CH2:28][NH:14][CH2:13][CH2:12][CH2:11][N:8]1[CH2:7][CH2:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][CH2:28][C:16]2[CH:17]=[CH:18][C:19]3[C:20]4[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:26][C:27]=3[CH:15]=2)[CH2:10][CH2:9]1

Participants

6

Reactant 4

HCID 962WaterHCID 34804Fluorene-2-carboxaldehydeHCID 816291,4-Bis(3-aminopropyl)piperazineHCID 4311764Sodium borohydride

Product 1

HCID 11621005HCID 11621005, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 1,4-bis(3-aminopropyl)piperazine (0.513 mL, 2.49 mmol) and 2-fluorenecarboxaldehyde (1.018 g, 5.24 mmol) in absolute ethanol (20 mL) was added 3 Å molecular sieves (5 g). After stirring the mixture for 12 h at room temperature, sodium borohydride (1.9 g, 49.9 mmol) was added and the mixture was stirred for 12 h at room temperature. Then the reaction mixture was quentched by dropwise addition of water (20 mL) and ethanol was removed under reduced pressure. The aqueous residue was extracted with CH2Cl2 (3×30 mL) and the combined organic layers were extracted with HCl 1N (2 25×50 mL). The combined aqueous layers were neutralized with NaOH 1N (50 mL) and extracted with CH2Cl2 (3×30 mL). The combined organic layers were dried over MgSO4, evaporated to dryness and the oily residue purified by flash chromatography (neutral aluminium oxide, CH2Cl2/MeOH: 90/10).

Workup

  1. stirringthe mixture was stirred for 12 h at room temperature
  2. customwas removed under reduced pressure
  3. extractionThe aqueous residue was extracted with CH2Cl2 (3×30 mL)
  4. extractionthe combined organic layers were extracted with HCl 1N (2 25×50 mL)
  5. extractionextracted with CH2Cl2 (3×30 mL)
  6. dry with materialThe combined organic layers were dried over MgSO4
  7. customevaporated to dryness
  8. customthe oily residue purified by flash chromatography (neutral aluminium oxide, CH2Cl2/MeOH: 90/10)

Sources & evidence

ORD record
ord-94f979aa292844a984b16280cfdb2646
Source dataset
uspto-grants-2015_06
Patent number
US09044478B2

Reaction notes

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